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eMediNexus 21 January 2022
Functional dyspepsia is known to be caused by diverse pathogenetic factors. From a clinical viewpoint, acid-related symptoms, like acid regurgitation, heartburn, and epigastric pain (acid-type) can be differentiated from the general dysmotility-type dyspeptic symptoms, such as fullness and nausea/vomiting.
A study evaluated the effect of a 4-week treatment with ranitidine twice a day in 346 patients and an antacid in 340 patients, with acid-related functional dyspepsia, on the severity and course of symptoms.
In acid-related functional dyspepsia, ranitidine appears to be a better drug compared to an antacid in relieving symptoms.
Source: Hotz J, Plein K, Bunke R. The effectiveness of ranitidine in non-ulcer dyspepsia (functional dyspepsia) in comparison with an antacid. Med Klin (Munich). 1994 Feb 15;89(2):73-80, 107.
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